Dr Sharifah Shahnaz binti Syed Abd Kadir

Designation

Clinical Hematologist

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Institution

Hospital Ampang

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Qualification

MD (UKM)

MRCP (UK)

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Special field of interest

Malignant haematology, stem cell transplantation, cellular therapy

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Abstract

Title:

Strategies to Tackle Transplant Associated Thrombotic Microangiopathy

Body:

The presentation explores strategies for managing thrombotic microangiopathy (TMA) post-stem cell transplant. Beginning with an overview of TMAâ??s definition, occurrence post-transplant, and its clinical significance, the presentation emphasizes the critical need for effective management strategies. Understanding the pathophysiology and diagnostic criteria of TMA sets the stage for discussing its association with various risk factors post-transplant, including conditioning regimens, graft-versus-host disease (GVHD), infections, and immunosuppressive therapies. Current treatment includes supportive care and pharmacological interventions like plasma exchange and eculizumab. Prevention strategies emphasize risk stratification and early detection. Case studies will be discussed, demonstrating challenges in diagnosis, and management. The presentation stresses multidisciplinary collaboration and the need for further research to optimize outcomes in managing TMA post-transplant.